Get Ambien After Knowing Its Interactions


Get Ambien After Knowing Its Interactions

Co-administration of Ambien (Zolpidem) along with other CNS depressants will increase the danger of CNS depression. Accompanying the use of the drug with CNS depressants may increase psychomotor impairment and drowsiness, including the marred driving ability.


A clinical study involving Ambien and Haloperidol actually demonstrated no effects of haloperidol on pharmacodynamics or pharmacokinetics of Ambien. The absence of drug interaction after a single dose does not foretell the lack of an effect after chronic administration.

Chlorpromazine, Imipramine

Imipramine along with Ambien generated no pharmacokinetic interactions apart from a 20 percent reduction in the peak level of imipramine. There was a known linear effect of less alertness. Likewise, chlorpromazine along with Ambien generated no pharmacokinetic interactions. Nevertheless, there was a linear effect of reduced psychomotor performance and alertness.


Accompanying use of zolpidem and sertraline in fact increased exposure to zolpidem.


An additive negative impact on psychomotor performance between oral zolpidem and alcohol was demonstrated.


After multiple dosages of fluoxetine and zolpidem, an increase in the half-life of zolpidem (17 percent) was noticed. There was no proof of a linear effect on psychomotor performance.

Medicines That Impact Drug Metabolism Through Cytochrome P450

Some chemical compounds known to inhibit or induce CYP3A may affect overall exposure to Ambien. The effect of medicines that inhibit or induce other P450 enzymes or proteins on exposure to Ambien is not known.

CYP3A4 Inducers

St. John’s Wort: Utilization of St. John’s Wort, which is a CYP3A4 inducer, along with Ambien may reduce the blood level of Ambien, and is certainly not recommended.

Rifampin: This is also a CYP3A4 inducer, which significantly reduced the pharmacodynamic effects of Ambien along with overall exposure. The use of rifampin with zolpidem might reduce the effectiveness of zolpidem and is usually not recommended.


The medication may cause some individuals, especially older people, to become drowsy, unsteady, lightheaded, or less attentive than before. Even though, Ambien is consumed at bedtime, it might cause some individuals to feel less alert or drowsy on arising. Moreover, the medicine might cause double vision problems. Furthermore, people should try to ensure that they know how to react to this drug before they drive, use heavy machines, or perform anything, which can be dangerous or risky if they are dizzy or not alerts.

If an individual develops any strange and unusual behavior or thoughts while taking Ambien, they should make sure to speak about this with a medical doctor. Some changes, which have happened in individuals taking this medication, are like those witnessed in people, who consume alcohol, and then behave in a way that is not normal.

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